Innovative approaches of targeted therapy for CML of childhood in combination with paediatric haematopoietic SCT

@article{Suttorp2008InnovativeAO,
  title={Innovative approaches of targeted therapy for CML of childhood in combination with paediatric haematopoietic SCT},
  author={Meinolf Suttorp},
  journal={Bone Marrow Transplantation},
  year={2008},
  volume={42},
  pages={S40-S46}
}
Allogeneic haematopoietic SCT (HSCT) induces CRs in most patients with CML. With the excellent short-term treatment results induced by imatinib (IMA), attitudes have changed and only a minority of children are now transplanted upfront. This review addresses the role of IMA in children with CML, focusing on the starting dose of IMA, possible adverse effects, timing of HSCT in children, duration of IMA treatment and monitoring of treatment efficacy to unravel failure of early treatment of IMA as… CONTINUE READING

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