Innovation in the pharmaceutical industry: New estimates of R&D costs.

@article{DiMasi2016InnovationIT,
  title={Innovation in the pharmaceutical industry: New estimates of R\&D costs.},
  author={Joseph A DiMasi and Henry G. Grabowski and Ronald W. Hansen},
  journal={Journal of health economics},
  year={2016},
  volume={47},
  pages={
          20-33
        }
}

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References

SHOWING 1-10 OF 51 REFERENCES

The price of innovation: new estimates of drug development costs.

Cost of innovation in the pharmaceutical industry.

The cost of biopharmaceutical R&D: is biotech different?

The results should be viewed with some caution for now given a limited number of biopharmaceutical molecules with data on cash outlays, different therapeutic class distributions for biophARMaceuticals and for pharmaceutical company drugs, and uncertainty about whether recent growth rates in pharmaceutical company costs are different from immediate past growth rates.

The R&D Cost of a New Medicine

The cost of R&D for a successful new medicine has been an important policy issue at least since the 1960s. Cost estimates matter not just because of intellectual curiosity or for industry

R&d Costs, Innovative Output and Firm Size in the Pharmaceutical Industry

This study examines the relationships between firm size, R&D costs and output in the pharmaceutical industry. Project-level data from a survey of 12 US-owned pharmaceutical firms on drug development

Research and Development Costs for New Drugs by Therapeutic Category

Development cost estimates by therapeutic category did not correlate strongly with US sales in the fifth year of marketing, but clinical development costs for Cardiovascular NCEs had much higher than average sales revenues but clinicaldevelopment costs for these drugs were only slightly above average.

Estimating the cost of new drug development: is it really 802 million dollars?

This paper replicates the drug development cost estimates of Joseph DiMasi and colleagues, using their published cost estimates along with information on success rates and durations from a publicly available data set, to estimate the cost per new drug between 1989 and 2002.

Decline in economic returns from new drugs raises questions about sustaining innovations.

Analysis of the economic returns for four cohorts of new prescription drugs launched in the United States and compared fluctuations in revenues with changing average research and development (R&D) and other costs found that the average present values of lifetime net economic returns were positive.

Spending on New Drug Development

The paper confirms earlier work by the authors that $802m may under estimate the average amount needed to bring a new molecular entity to market and confirms that there is significant variation in spending by therapeutic category.

RESEARCH AND DEVELOPMENT IN THE PHARMACEUTICAL INDUSTRY.

  • A. Smith
  • Political Science
    Dental student
  • 1965
Basic facts about the drug industry's recent spending on research and development (R&D) and its output of new drugs are reviewed and the role of expected profits in private firms' decisions about investing in drug R&D is examined.
...