Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal.

@article{Kreipke2015InnervatingSN,
  title={Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal.},
  author={Rebecca Ellen Kreipke and Susan J. Birren},
  journal={The Journal of physiology},
  year={2015},
  volume={593 23},
  pages={
          5057-73
        }
}
Sympathetic drive to the heart is a key modulator of cardiac function and interactions between heart tissue and innervating sympathetic fibres are established early in development. Significant innervation takes place during postnatal heart development, a period when cardiomyocytes undergo a rapid transition from proliferative to hypertrophic growth. The question of whether these innervating sympathetic fibres play a role in regulating the modes of cardiomyocyte growth was investigated using 6… CONTINUE READING
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