Inner ear hair cell-like cells from human embryonic stem cells.

@article{Ronaghi2014InnerEH,
  title={Inner ear hair cell-like cells from human embryonic stem cells.},
  author={Mohammad Hossein Ronaghi and Marjan Nasr and Megan Ealy and Robert Durruthy-Durruthy and Joerg Waldhaus and Giovanni Diaz and Lydia-Marie Joubert and Kazuo Oshima and Stefan Heller},
  journal={Stem cells and development},
  year={2014},
  volume={23 11},
  pages={
          1275-84
        }
}
In mammals, the permanence of many forms of hearing loss is the result of the inner ear's inability to replace lost sensory hair cells. Here, we apply a differentiation strategy to guide human embryonic stem cells (hESCs) into cells of the otic lineage using chemically defined attached-substrate conditions. The generation of human otic progenitor cells was dependent on fibroblast growth factor (FGF) signaling, and protracted culture led to the upregulation of markers indicative of… CONTINUE READING

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Cell Therapy Development in Hearing Loss

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CITES BACKGROUND
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Single-cell analysis delineates a trajectory toward the human early otic lineage.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
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CITES METHODS & BACKGROUND

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