Inner cell mass localization of NANOG precedes OCT3/4 in rhesus monkey blastocysts.

@article{Harvey2009InnerCM,
  title={Inner cell mass localization of NANOG precedes OCT3/4 in rhesus monkey blastocysts.},
  author={Alexandra J Harvey and David Randall Armant and Barry D. Bavister and Stephanie M Nichols and Carol A. Brenner},
  journal={Stem cells and development},
  year={2009},
  volume={18 10},
  pages={1451-8}
}
The mechanism by which the inner cell mass (ICM) and trophectoderm (TE) become specified is poorly understood. Considerable species variation is evident in the expression of lineage-specific and embryonic stem cell (ESC) regulatory markers. We sought to investigate localization patterns of these markers in rhesus macaque compact morulae and blastocysts. NANOG protein was restricted to the ICM of blastocysts. In contrast to a previous report, the expression of CDX2 was detected in the primate… CONTINUE READING

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