Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine.

@article{Tournier2013InnatelyLD,
  title={Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine.},
  author={Benjamin B. Tournier and Thierry Steimer and Philippe Millet and Marcelle Moulin-Sallanon and Philippe G Vallet and Vicente Ib{\'a}{\~n}ez and Nathalie Ginovart},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 8},
  pages={1819-34}
}
High novelty-seeking has been related to an increased risk for developing addiction, but the neurobiological mechanism underlying this relationship is unclear. We investigated whether differences in dopamine (DA) D2/3-receptor (D2/3R) function underlie phenotypic divergence in novelty-seeking and vulnerability to addiction. Measures of D2/3R availability using the D2R-preferring antagonist [18F]Fallypride, and the D3R-preferring agonist [3H]-(+)-PHNO and of DA-related gene expression and… CONTINUE READING
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