Innate sensors of influenza virus: clues to developing better intranasal vaccines.

  title={Innate sensors of influenza virus: clues to developing better intranasal vaccines.},
  author={Takeshi Ichinohe and Akiko Iwasaki and Hideki Hasegawa},
  journal={Expert review of vaccines},
  volume={7 9},
Mucosal immunity acquired by natural infection with influenza viruses at the respiratory tract is more effective and cross-protective against subsequent variant virus infection than systemic immunity induced by parenteral immunization with inactivated vaccines. To develop an effective influenza vaccine, it is beneficial to mimic the process of natural infection that bridges innate and adaptive immune systems. The innate immune system that recognizes influenza virus infection consists of several… CONTINUE READING
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