Innate or adaptive immunity? The example of natural killer cells.

@article{Vivier2011InnateOA,
  title={Innate or adaptive immunity? The example of natural killer cells.},
  author={Eric Vivier and David H Raulet and Alessandro Moretta and Michael A. Caligiuri and Laurence Zitvogel and Lewis L. Lanier and Wayne M Yokoyama and Sophie Ugolini},
  journal={Science},
  year={2011},
  volume={331 6013},
  pages={
          44-9
        }
}
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to… CONTINUE READING

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