Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A.

@article{Kim2018InnatelikeCF,
  title={Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A.},
  author={Jihye Kim and Dong-Yeop Chang and Hyun Woong Lee and Hoyoung Lee and Jong Hoon Kim and Pil Soo Sung and Kyung Hwan Kim and Seon-Hui Hong and Wonseok Kang and Jino Lee and So Youn Shin and Hee Tae Yu and Sooseong You and Yoon Seok Choi and Insoo Oh and Dong Ho Lee and Dong Hyeon Lee and Min Kyung Jung and Kyung Suk Suh and Shin Won Hwang and Won Kim and S Park and Hyung Joon Kim and Eui-Cheol Shin},
  journal={Immunity},
  year={2018},
  volume={48 1},
  pages={
          161-173.e5
        }
}
Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent activation of non-HAV-specific CD8+ T cells were detected in patients, as indicated by NKG2D upregulation, a marker of TCR-independent T cell activation by IL-15. CD8+ T cells derived… CONTINUE READING
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