Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses.

@article{Fujimoto2013InnateIB,
  title={Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses.},
  author={Yukari Fujimoto and Atsushi Shimoyama and Akinori Saeki and Naohiro Kitayama and Chika Kasamatsu and Hiroko Tsutsui and Koichi Fukase},
  journal={Molecular bioSystems},
  year={2013},
  volume={9 5},
  pages={987-96}
}
Synthetic studies of lipid A and LPS partial structures have been performed to investigate the relationship between structures and functions of LPS. Recent studies have suggested several pathological implications of LPS from parasitic bacteria due to its influence on the host immune responses. To address this issue, we established an efficient synthetic strategy that is widely applicable to the synthesis of various lipid As by using a key disaccharide intermediate with selectively cleavable… CONTINUE READING