Innate immunity to dengue virus infection and subversion of antiviral responses.

@article{Green2014InnateIT,
  title={Innate immunity to dengue virus infection and subversion of antiviral responses.},
  author={Angela M. Green and P. Robert Beatty and Alexandros Hadjilaou and Eva Harris},
  journal={Journal of molecular biology},
  year={2014},
  volume={426 6},
  pages={1148-60}
}
Dengue is a major public health issue in tropical and subtropical regions worldwide. The four serotypes of dengue virus (DENV1-DENV4) are spread primarily by Aedes aegypti and Aedes albopictus mosquitoes, whose geographic range continues to expand. Humans are the only host for epidemic strains of DENV, and the virus has developed sophisticated mechanisms to evade human innate immune responses. The host cell's first line of defense begins with an intracellular signaling cascade resulting in… CONTINUE READING
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