Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease.

Abstract

Evidence from in vitro studies suggests that gamma interferon (IFN-gamma) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with targeted disruption of the IFN-gamma receptor gene and mice with targeted disruption of the gene encoding inducible NO synthase to show that IFN-gamma plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is required for control of amebic liver abscess in immunocompetent mice.

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@article{Seydel2000InnateIT, title={Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease.}, author={Karl Seydel and S J Smith and Samuel L. Stanley}, journal={Infection and immunity}, year={2000}, volume={68 1}, pages={400-2} }