Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8+ T cells during MCMV infection

@article{Mitrovi2012InnateIR,
  title={Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8+ T cells during MCMV infection},
  author={Maja Mitrovi{\'c} and Jurica Arapovic and Luka Traven and Astrid Krmpotic and Stipan Jonji{\'c}},
  journal={Medical Microbiology and Immunology},
  year={2012},
  volume={201},
  pages={487-495}
}
Natural killer (NK) cells play a crucial role in early immune response against cytomegalovirus infection. A large and mounting body of data indicate that these cells are involved in the regulation of the adaptive immune response as well. By using mouse cytomegalovirus (MCMV) as a model, several groups provided novel insights into the role of NK cells in the development and kinetics of antiviral CD8+ T cell response. Depending on infection conditions, virus strain and the genetic background of… CONTINUE READING

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