Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways.

Abstract

Recent studies have implicated Toll-like receptor 2 (TLR2) and TLR4 signaling in delimiting liver and brain injury following ischemia-reperfusion (I/R). To determine whether TLR2 and TLR4 conferred cytoprotection in the heart, we subjected hearts of wild-type (WT) mice and mice deficient in TLR2 (TLR2D), TLR4 (TLR4D), and TIR domain-containing adapter… (More)
DOI: 10.1152/ajpheart.00306.2009

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@article{Dong2010InnateIM, title={Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways.}, author={Jian-Wen Dong and Jesus G. Vallejo and Huei-Ping Tzeng and James A. Thomas and Douglas L. Mann}, journal={American journal of physiology. Heart and circulatory physiology}, year={2010}, volume={298 3}, pages={H1079-87} }