Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity.

@article{Gao2003InnateIM,
  title={Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity.},
  author={Wentao Gao and S. Kiran Kumar and Michael T Lotze and Charles R. Hanning and Paul D. Robbins and Andrea A. Gambotto},
  journal={Journal of immunology},
  year={2003},
  volume={170 1},
  pages={107-13}
}
Recently, several novel members of the IL-1 family have been identified. The possible therapeutic utility and the underlying biologic role of these new members remain unclear. In the present study we analyzed the anti-tumor activity of human IL-1 homologue 4(IL-1H4; renamed IL-F7) by adenovirus-mediated gene transfer (AdIL-1H4) directly into murine tumors. In vitro expression analysis showed that IL-1H4 was a secretory protein. Treatment of an established MCA205 mouse fibrosarcoma by single… CONTINUE READING
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