Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response.

@article{Karni2006InnateII,
  title={Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response.},
  author={Arnon Karni and Michal Abraham and Alon Monsonego and Guifang Cai and Gordon J Freeman and David A. Hafler and Samia J Khoury and Howard L. Weiner},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={4196-202}
}
Multiple sclerosis (MS) is postulated to be a T cell-mediated autoimmune disease characterized clinically by a relapsing-remitting (RR) stage followed by a secondary progressive (SP) phase. The progressive phase is felt to be secondary to neuronal degenerative changes triggered by inflammation. The status of the innate immune system and its relationship to the stages of MS is not well understood. Dendritic cells (DCs) are professional APCs that are central cells of the innate immune system and… CONTINUE READING

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