Innate immunity in atopic dermatitis.

  title={Innate immunity in atopic dermatitis.},
  author={Andreas Wollenberg and Helen-Caroline R{\"a}wer and J{\"u}rgen Schauber},
  journal={Clinical reviews in allergy & immunology},
  volume={41 3},
Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease. In AD patients, the combination of a genetic predisposition for skin barrier dysfunction and dysfunctional innate and adaptive immune responses leads to a higher frequency of bacterial and viral skin infections. The innate immune system quickly mobilizes an unspecific, standardized first-line defense against different pathogens. Defects in this system lead to barrier dysfunction which results in… CONTINUE READING


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