Innate immunity drives xenobiotic-induced murine autoimmune cholangitis.

  title={Innate immunity drives xenobiotic-induced murine autoimmune cholangitis.},
  author={C Chang and Y Chen and Y Yu and M-H Tao and Patrick S. C. Leung and Aftab A Ansari and M Eric Gershwin and Y Y Chuang},
  journal={Clinical and experimental immunology},
  volume={177 2},
Although primary biliary cirrhosis (PBC) is considered a model autoimmune disease, it has not responded therapeutically to traditional immunosuppressive agents. In addition, PBC may recur following liver transplantation, despite the absence of major histocompatibility complex (MHC) matching, in sharp contrast to the well-known paradigm of MHC restriction. We have suggested previously that invariant natural killer T (iNK T) cells are critical to the initiation of PBC. In this study we have taken… CONTINUE READING
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