Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.

@article{Fiala2007InnateIA,
  title={Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.},
  author={Milan Fiala and Philip T. Liu and Araceli Espinosa-Jeffrey and Mark J. Rosenthal and George Bernard and John M. Ringman and James Sayre and Laura Y Zhang and Justin Zaghi and Sheila Z Dejbakhsh and Ben Y. Chiang and James Hui and Michelle Mahanian and Anita Baghaee and Pamela Hong and John Cashman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 31},
  pages={12849-54}
}
We have tested a hypothesis that the natural product curcuminoids, which has epidemiologic and experimental rationale for use in AD, may improve the innate immune system and increase amyloid-beta (Abeta) clearance from the brain of patients with sporadic Alzheimer's disease (AD). Macrophages of a majority of AD patients do not transport Abeta into endosomes… CONTINUE READING