Innate immunity and toll-like receptors: clinical implications of basic science research.

@article{Abreu2004InnateIA,
  title={Innate immunity and toll-like receptors: clinical implications of basic science research.},
  author={Maria T. Abreu and Moshe Arditi},
  journal={The Journal of pediatrics},
  year={2004},
  volume={144 4},
  pages={421-9}
}
Humans are constantly exposed to a wide variety of microorganisms that can cause infection. In self-defense, the human host has evolved complex protective mechanisms, and Toll-like receptors (TLRs) have emerged as a central point in defense. These receptors bind molecular structures that are expressed by microbes but are not expressed by the human host, eg, lipopolysaccharides (LPS) or double-stranded RNA (dsRNA). Activation of these receptors initiates an inflammatory cascade that attempts to… CONTINUE READING

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