Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice.

@article{Reddy2009InnateIA,
  title={Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice.},
  author={Narsa M. Reddy and Vegiraju Suryanarayana and Dhananjaya V. Kalvakolanu and Masayuki Yamamoto and Thomas Wells Kensler and Paul M Hassoun and Steven R. Kleeberger and Sekhar P. M. Reddy},
  journal={Journal of immunology},
  year={2009},
  volume={183 7},
  pages={
          4601-8
        }
}
Oxygen supplementation is used as therapy to support critically ill patients with severe respiratory impairment. Although hyperoxia has been shown to enhance the lung susceptibility to subsequent bacterial infection, the mechanisms underlying enhanced susceptibility remain enigmatic. We have reported that disruption of NF-E2-related factor 2 (Nrf2), a master transcription regulator of various stress response pathways, enhances susceptibility to hyperoxia-induced acute lung injury in mice, and… CONTINUE READING

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