Innate immunity against HIV-1 infection

@article{Altfeld2015InnateIA,
  title={Innate immunity against HIV-1 infection},
  author={Marcus Altfeld and Michael Gale},
  journal={Nature Immunology},
  year={2015},
  volume={16},
  pages={554-562}
}
During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling cascade that initiates innate intracellular antiviral defenses aimed at restricting the replication and spread of the virus. This cell-intrinsic response propagates outward via the action of secreted factors such as cytokines and chemokines that activate innate immune cells and attract them to the site of infection and… Expand
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