Innate immunity, local inflammation, and degenerative disease.

  title={Innate immunity, local inflammation, and degenerative disease.},
  author={Patrick L. Mcgeer and E. G. McGeer P. L. McGeer},
  journal={Science of aging knowledge environment : SAGE KE},
  volume={2002 29},
The brain lesions associated with Alzheimer's disease (AD), which are referred to as neurofibrillary tangles and senile plaques, are characterized by the presence of a broad spectrum of inflammatory mediators. Surprisingly, these mediators, which include complement proteins, inflammatory cytokines, prostaglandins, and acute phase reactants such as C-reactive protein and amyloid P, are produced by resident brain cells, including neurons. Although secondary to the fundamental pathology caused by… CONTINUE READING