Innate immune responses to influenza A H5N1: friend or foe?

@article{Peiris2009InnateIR,
  title={Innate immune responses to influenza A H5N1: friend or foe?},
  author={Joseph Sriyal Malik Peiris and Chung Yan Cheung and Connie Yin Hung Leung and John Malcolm Nicholls},
  journal={Trends in immunology},
  year={2009},
  volume={30 12},
  pages={574-84}
}
Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the… CONTINUE READING
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