Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution.

@article{Sen2012InnateIR,
  title={Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution.},
  author={Adrish Sen and Michael E. Rothenberg and Gourab Mukherjee and Ningguo Feng and Tomer Kalisky and Nitya Nair and Iain M. Johnstone and Michael F. Clarke and Harry B Greenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 50},
  pages={20667-72}
}
"Bulk" measurements of antiviral innate immune responses from pooled cells yield averaged signals and do not reveal underlying signaling heterogeneity in infected and bystander single cells. We examined such heterogeneity in the small intestine during rotavirus (RV) infection. Murine RV EW robustly activated type I IFNs and several antiviral genes (IFN-stimulated genes) in the intestine by bulk analysis, the source of induced IFNs primarily being hematopoietic cells. Flow cytometry and… CONTINUE READING

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