Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways.

@article{Zhu2007InnateIR,
  title={Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways.},
  author={Jiangao Zhu and Xiaopei Huang and Yiping Yang},
  journal={Journal of virology},
  year={2007},
  volume={81 7},
  pages={3170-80}
}
Recombinant adenoviral vectors have been widely used for gene therapy applications and as vaccine vehicles for treating infectious diseases such as human immunodeficiency virus disease. The innate immune response to adenoviruses represents the most significant hurdle in clinical application of adenoviral vectors for gene therapy, but it is an attractive feature for vaccine development. How adenovirus activates innate immunity remains largely unknown. Here we showed that adenovirus elicited… CONTINUE READING
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