Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation.

@article{Bergsbaken2009InnateIR,
  title={Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation.},
  author={Tessa Bergsbaken and Brad T. Cookson},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={86 5},
  pages={1153-8}
}
Yersinia pestis, the etiological agent of plague, is one of the most deadly pathogens on our planet. This organism shares important attributes with its ancestral progenitor, Yersinia pseudotuberculosis, including a 70-kb virulence plasmid, lymphotropism during growth in the mammalian host, and killing of host macrophages. Infections with both organisms are biphasic, where bacterial replication occurs initially with little inflammation, followed by phagocyte influx, inflammatory cytokine… CONTINUE READING

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