Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5

Abstract

Methods for human skin gene therapy requires efficient and stable introduction of genes into skin cells. Transient cutaneous gene therapy is an attractive approach in the treatment of skin diseases. The 'Achilles heel' of adenoviral gene therapy is its immunogenicity and many aspects of adenovirus induced cutaneous immune reaction still remain unanswered… (More)
DOI: 10.1186/2193-1801-2-234

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