Innate immune recognition.

@article{Janeway2002InnateIR,
  title={Innate immune recognition.},
  author={Charles A. Jr Janeway and Ruslan Medzhitov},
  journal={Annual review of immunology},
  year={2002},
  volume={20},
  pages={
          197-216
        }
}
The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Toll-like receptors play a major role in pathogen recognition… 
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