Innate immune recognition of viral infection

@article{Kawai2006InnateIR,
  title={Innate immune recognition of viral infection},
  author={Taro Kawai and Shizuo Akira},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={131-137}
}
Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type I interferon and inflammatory cytokines and leads to dendritic cell maturation and establishment of antiviral immunity. Cells also express cytoplasmic RNA helicases that function… Expand
Innate immune recognition of viral infection.
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Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids and induce type I interferon responses via distinct signaling pathways. Expand
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The current understanding of nucleic acid sensing by innate immune receptors is highlighted and the regulatory mechanisms that normally prevent inappropriate responses to self are discussed. Expand
Viral regulation and evasion of the host response.
  • Y. Loo, M. Gale
  • Biology, Medicine
  • Current topics in microbiology and immunology
  • 2007
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This work provides a review of the virus/host processes involved in IFN signaling and regulation of innate immune defenses and demonstrates that many viruses, including hepatitis C virus, direct processes to control the host response to infection. Expand
Toll-like Receptors and Type I Interferons*
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This review discusses the recent findings of the viral recognition by TLRs and their signaling pathways and discusses the role of ligand recognition in this recognition. Expand
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