Innate immune mechanisms in transplant allograft vasculopathy.

Abstract

PURPOSE OF REVIEW Allograft vasculopathy is the leading cause of late allograft loss following solid organ transplantation. Ischemia reperfusion injury and donor-specific antibody-induced complement activation confer heightened risk for allograft vasculopathy via numerous innate immune mechanisms, including MyD88, high-mobility group box 1 (HMGB1), and… (More)
DOI: 10.1097/MOT.0000000000000314

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