Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

@article{Navarini2009InnateID,
  title={Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.},
  author={Alexander Navarini and Karl S Lang and Admar Verschoor and Mike Recher and Annelies Sophie Zinkernagel and Victor Nizet and Bernhard M Odermatt and Hans Hengartner and Rolf Martin Zinkernagel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 17},
  pages={7107-12}
}
Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of… CONTINUE READING