Innate immune evasion strategies of DNA and RNA viruses.

  title={Innate immune evasion strategies of DNA and RNA viruses.},
  author={Dia C. Beachboard and Stacy M Horner},
  journal={Current opinion in microbiology},
Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interferons, as well as other antiviral genes that together mediate viral clearance and inhibit viral spread. Therefore, in order for viruses to replicate and spread efficiently, they must… CONTINUE READING