Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition.

@article{Cvetanovic2004InnateID,
  title={Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition.},
  author={Marija Cvetanovic and David S. Ucker},
  journal={Journal of immunology},
  year={2004},
  volume={172 2},
  pages={
          880-9
        }
}
  • Marija Cvetanovic, David S. Ucker
  • Published in Journal of immunology 2004
  • Biology, Medicine
  • Physiological cell death is a process the purpose of which is the elimination of functionally inappropriate cells in a manner that does not elicit an inflammatory response. We have shown previously that the ability of apoptotic corpses to be recognized by macrophages and to modulate the proinflammatory responses of those cells represents paradoxically a gain-of-function acquired during the physiological cell death process. Cells that die pathologically (that is, necrotic vs apoptotic corpses… CONTINUE READING

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