Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

@article{Kallionp2014InnateIA,
  title={Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.},
  author={Henna Kallionp{\"a}{\"a} and Laura L. Elo and Essi Laajala and Juha Mykk{\"a}nen and Isis Rica{\~n}o-Ponce and Matti Vaarma and Teemu Daniel Laajala and Heikki Hy{\"o}ty and Jorma Ilonen and Riitta K. Veijola and Tuula T. Simell and Cisca Wijmenga and Mikael Knip and Harri L{\"a}hdesm{\"a}ki and Olli G. Simell and Riitta Lahesmaa},
  journal={Diabetes},
  year={2014},
  volume={63 7},
  pages={
          2402-14
        }
}
The insult leading to autoantibody development in children who will progress to develop type 1 diabetes (T1D) has remained elusive. To investigate the genes and molecular pathways in the pathogenesis of this disease, we performed genome-wide transcriptomics analysis on a unique series of prospective whole-blood RNA samples from at-risk children collected in the Finnish Type 1 Diabetes Prediction and Prevention study. We studied 28 autoantibody-positive children, out of which 22 progressed to… CONTINUE READING
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Similar Papers

Loading similar papers…