Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

@article{Torren2015InnateAA,
  title={Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy},
  author={C. R. van der Torren and A. Zaldumbide and D. Roelen and G. Duinkerken and S. H. Brand-Schaaf and M. Peakman and P. Czernichow and P. Ravassard and R. Scharfmann and B. Roep},
  journal={Diabetologia},
  year={2015},
  volume={59},
  pages={170 - 175}
}
Aims/hypothesisGenetically engineered human beta cell lines provide a novel source of human beta cells to study metabolism, pharmacology and beta cell replacement therapy. Since the immune system is essentially involved in beta cell destruction in type 1 diabetes and after beta cell transplantation, we investigated the interaction of human beta cell lines with the immune system to resolve their potential for immune intervention protocol studies.MethodsHuman pancreatic beta cell lines (EndoC-βH1… Expand
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References

SHOWING 1-10 OF 14 REFERENCES
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion.
T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins
Anti-EGFR Antibody Cetuximab Enhances the Cytolytic Activity of Natural Killer Cells toward Osteosarcoma
...
1
2
...