Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation.

@article{Sta2011InnateAA,
  title={Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation.},
  author={Matthew Sta and Regien M. R. Sylva-Steenland and Milena Casula and J M B Vianney de Jong and Dirk Troost and E. Aronica and Frank Baas},
  journal={Neurobiology of disease},
  year={2011},
  volume={42 3},
  pages={211-20}
}
Increasing evidence suggests a role for the immune system in amyotrophic lateral sclerosis (ALS). To determine the extent of the immune activation in ALS we analyzed the expression and cellular distribution of components of innate and adaptive immunity in spinal cord (SC) and motor cortex (MCx) from patients with rapid and slow sporadic ALS and controls. High levels of mRNA and protein of classical complement pathway, C1q and C4, as well as the downstream complement components C3 and C5b-9 were… CONTINUE READING
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