Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.

@article{Ravizza2008InnateAA,
  title={Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.},
  author={Teresa Ravizza and Barbara Gagliardi and Francesco Mattia No{\`e} and Karin de Boer and E. Aronica and Annamaria Vezzani},
  journal={Neurobiology of disease},
  year={2008},
  volume={29 1},
  pages={142-60}
}
We investigated the activation of the IL-1 beta system and markers of adaptive immunity in rat brain during epileptogenesis using models of temporal lobe epilepsy (TLE). The same inflammatory markers were studied in rat chronic epileptic tissue and in human TLE with hippocampal sclerosis (HS). IL-1 beta was expressed by both activated microglia and astrocytes within 4 h from the onset of status epilepticus (SE) in forebrain areas recruited in epileptic activity; however, only astrocytes… CONTINUE READING
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