Innate and adaptive immune traits are differentially affected by genetic and environmental factors

@inproceedings{Mangino2017InnateAA,
  title={Innate and adaptive immune traits are differentially affected by genetic and environmental factors},
  author={Massimo Mangino and Mario Roederer and Margaret H. Beddall and Frank O. Nestle and Tim D. Spector},
  booktitle={Nature communications},
  year={2017}
}
The diversity and activity of leukocytes is controlled by genetic and environmental influences to maintain balanced immune responses. However, the relative contribution of environmental compared with genetic factors that affect variations in immune traits is unknown. Here we analyse 23,394 immune phenotypes in 497 adult female twins. 76% of these traits show a predominantly heritable influence, whereas 24% are mostly influenced by environment. These data highlight the importance of shared… CONTINUE READING

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