Innate and adaptive immune activation in the brain of MPS IIIB mouse model.

@article{Dirosario2009InnateAA,
  title={Innate and adaptive immune activation in the brain of MPS IIIB mouse model.},
  author={Julianne D Dirosario and Erin Divers and Chuansong Wang and Jonathan Etter and Alyssa Charrier and Peter Jukkola and Herbert J. Auer and Victoria Maria Best and David L. Newsom and Douglas M Mccarty and Haiyan Fu},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 4},
  pages={
          978-90
        }
}
Mucopolysaccharidosis (MPS) IIIB is a lysosomal storage disease with severe neurological manifestations due to alpha-N-acetylglucosaminidase (NaGlu) deficiency. The mechanism of neuropathology in MPS IIIB is unclear. This study investigates the role of immune responses in neurological disease of MPS IIIB in mice. By means of gene expression microarrays and real-time quantitative reverse transcriptase-polymerase chain reaction, we demonstrated significant up-regulation of numerous immune-related… CONTINUE READING
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