Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia

@inproceedings{Choi2013InnateSI,
  title={Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia},
  author={Sun-Mi Choi and Jeremy P. McAleer and Mingquan Zheng and Derek A Pociask and Mark H Kaplan and Shulin Qin and Todd A. Reinhart and Jay K Kolls},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Pulmonary Staphylococcus aureus (SA) infections are a public health concern and a major complication of hyper-IgE syndrome, caused by mutations in STAT3. In contrast to previous findings of skin infection, we observed that clearance of SA from the lung did not require T, B, or NK cells but did require Stat3 activation. Immunohistochemistry showed robust Stat3 phosphorylation in the lung epithelium. We identified that a critical Stat3 target gene in lung epithelium is Reg3g (regenerating islet… CONTINUE READING