Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.

  title={Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.},
  author={Amanda L. Prince and Levi B. Watkin and Catherine C. Yin and Liisa K. Selin and Joonsoo Kang and Pamela L Schwartzberg and Leslie J Berg},
  journal={Journal of immunology},
  volume={193 2},
T cell development in the thymus produces multiple lineages of cells, including innate T cells. Studies in mice harboring alterations in TCR signaling proteins or transcriptional regulators have revealed an expanded population of CD4(+) innate T cells in the thymus that produce IL-4 and express the transcription factor promyelocytic leukemia zinc finger (PLZF). In these mice, IL-4 produced by the CD4(+)PLZF(+) T cell population leads to the conversion of conventional CD8(+) thymocytes into… CONTINUE READING
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