Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

  title={Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria},
  author={Gregory F. Sonnenberg and L. Monticelli and T. Alenghat and T. Fung and N. Hutnick and J. Kunisawa and N. Shibata and S. Grunberg and R. Sinha and A. Zahm and M. Tardif and Taheri Sathaliyawala and M. Kubota and D. Farber and R. Collman and A. Shaked and L. Fouser and D. Weiner and P. Tessier and J. Friedman and H. Kiyono and F. Bushman and K. Chang and D. Artis},
  pages={1321 - 1325}
  • Gregory F. Sonnenberg, L. Monticelli, +21 authors D. Artis
  • Published 2012
  • Biology, Medicine
  • Science
  • Protecting Against a Barrier Breach In order to coexist peacefully, a “firewall” exists that keeps the commensal bacteria that reside in our intestines and associated lymphoid tissue contained. Several diseases and infections, however, lead to a breach in this barrier, which leads to chronic inflammation and pathology. Sonnenberg et al. (p. 1321) found that in mice, innate lymphoid cells (ILCs) are critically important for the anatomical containment of commensal bacteria in an interleukin-22… CONTINUE READING
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