Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

@article{Lampron2013InnateII,
  title={Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment},
  author={Antoine Lampron and Ayman ElAli and Serge Rivest},
  journal={Neuron},
  year={2013},
  volume={78},
  pages={214-232}
}
The concept of the CNS as an immune-privileged organ has led to a common misunderstanding that it is not an active immunological organ, guarded from its surroundings by the blood-brain barrier (BBB). Recent advances in this field clearly demonstrate that the CNS is a highly immunologically active organ, with complex immune responses mostly based on innate immune processes. Such responses implicate a continuum of heterogeneous cell types both inside the CNS, in the periphery, and at their… CONTINUE READING
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