Innate Immunity confounds the clinical efficacy of small interfering RNAs (siRNAs)

  title={Innate Immunity confounds the clinical efficacy of small interfering RNAs (siRNAs)},
  author={John J. Rossi},
  journal={Gene Therapy},
Small interfering RNAs (siRNAs) are double stranded, sequence-specific inhibitors of gene expression. They act by incorporation into the catalytic domain of an Argonaute family protein serving as guides for a complex that functionally destroys the target. The discovery that they can trigger site-specific cleavage in the absence of type I interferon induction. has led to a plethora of inhibitory applications for these small duplexes in mammalian systems. However, several recent findings… CONTINUE READING
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