Innate Immunity confounds the clinical efficacy of small interfering RNAs (siRNAs)

@article{Rossi2009InnateIC,
  title={Innate Immunity confounds the clinical efficacy of small interfering RNAs (siRNAs)},
  author={John J. Rossi},
  journal={Gene Therapy},
  year={2009},
  volume={16},
  pages={579-580}
}
Small interfering RNAs (siRNAs) are double stranded, sequence-specific inhibitors of gene expression. They act by incorporation into the catalytic domain of an Argonaute family protein serving as guides for a complex that functionally destroys the target. The discovery that they can trigger site-specific cleavage in the absence of type I interferon induction. has led to a plethora of inhibitory applications for these small duplexes in mammalian systems. However, several recent findings… CONTINUE READING
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5 0TriphosphatesiRNA : turning gene silencing and RigI activation against melanoma

  • H Poeck, R Besch, C Maihoefer, M Renn, D Tormo, SS Morskaya
  • Nature Medicine
  • 2008

Misinterpret - ing the therapeutic effects of siRNA caused by immune stimulation

  • M Robbins, A Judge, E Ambegia, C Choi, E Yaworski, L Palmer
  • Human Gene Therapy
  • 2008

2 0Omethylmodified RNAs act as TLR 7 antagonists

  • M Robbins, A Judge, L Liang, K McClintock, E Yaworski, I. MacLachlan
  • Mol Ther
  • 2007

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