Innate Immunity Fights Alzheimer's Disease.

  title={Innate Immunity Fights Alzheimer's Disease.},
  author={Marie-Victoire Guillot-Sestier and Kevin R. Doty and Terrence C. Town},
  journal={Trends in neurosciences},
  volume={38 11},
Alzheimer's disease (AD) is the most common age-related dementia. Pathognomonic accumulation of cerebral β-amyloid plaques likely results from imbalanced production and removal of amyloid-β (Aβ) peptides. In AD, innate immune cells lose their ability to restrict cerebral Aβ accumulation. At least in principle, mononuclear phagocytes can be enlisted to clear Aβ/β-amyloid from the brain. While the classical focus has been on dampening neuroinflammation in the context of AD, we hypothesize that… CONTINUE READING
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