Innate Immunity: Ignored for decades, but not forgotten

  title={Innate Immunity: Ignored for decades, but not forgotten},
  author={Robert L Modlin},
  booktitle={The Journal of investigative dermatology},
The innate immune system must recognize and rapidly respond to microbial pathogens, providing a first line of host defense. This is accomplished through an array of pattern recognition receptors (PRRs) that reside in specific subcellular compartments and can bind pathogen-associated molecular patterns. PRRs also recognize self-molecules that are released after cell damage or death, known as danger-associated molecular patterns, which can be actively transported across cell membranes. The… CONTINUE READING
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