Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila

@article{Ryu2008InnateIH,
  title={Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila},
  author={Ji-Hwan Ryu and Sung-Hee Kim and Hyo Young Lee and J. Y. Bai and Young-Do Nam and Jin-Woo Bae and Dong Gun Lee and Seung Chul Shin and Eun-Mi Ha and Won Jae Lee},
  journal={Science},
  year={2008},
  volume={319},
  pages={777 - 782}
}
Although commensalism with gut microbiota exists in all metazoans, the host factors that maintain this homeostatic relationship remain largely unknown. We show that the intestinal homeobox gene Caudal regulates the commensal-gut mutualism by repressing nuclear factor kappa B–dependent antimicrobial peptide genes. Inhibition of Caudal expression in flies via RNA interference led to overexpression of antimicrobial peptides, which in turn altered the commensal population within the intestine. In… 
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743 Citations

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