Innate IL-17-producing cells: the sentinels of the immune system

@article{Cua2010InnateIC,
  title={Innate IL-17-producing cells: the sentinels of the immune system},
  author={Daniel J. Cua and Cristina M Tato},
  journal={Nature Reviews Immunology},
  year={2010},
  volume={10},
  pages={479-489}
}
  • D. Cua, C. Tato
  • Published 1 July 2010
  • Biology
  • Nature Reviews Immunology
The cytokine interleukin-17 (IL-17) has received considerable attention since the discovery of a distinct CD4+ T helper (TH) cell subset that produces it, known as the TH17 cell subset. Despite the fact that most of the recent literature describes IL-17 as a T cell-secreted cytokine, much of the IL-17 released during an inflammatory response is produced by innate immune cells. In this Review, we explore the many innate immune cell populations that are an early source of IL-17 in response to… 
IL-17 cytokines in immunity and inflammation
  • W. Jin, C. Dong
  • Biology, Medicine
    Emerging Microbes & Infections
  • 2013
TLDR
Knowing the regulatory mechanisms of IL-17 expression and signaling mechanisms will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients.
Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders.
TLDR
IL-17 T cells are reviewed exclusively in the human situation and more specifically their potential role in respiratory diseases and advances in the understanding of IL-17 regulation offer opportunities to dissect the human IL- 17 system and to reflect on the clinical presentation of lung diseases.
Role of interleukin (IL)-17 and T-helper (Th)17 cells in cancer.
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
TLDR
This Review focuses on the recent advances that have been made regarding the transcriptional control of TH 17 cell plasticity and stability, as well as the effector functions of TH17 cells, and highlights the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues.
IL-17A Family, Receptors, Proinflammatory Effects, and Production
TLDR
The identification of IL-17A and, later on, of Th17 cells has modified the established Th1 and Th2 paradigm, led to the definition of a new CD3+ CD4+ effector T cell subset, and introduced a new paradigm to explain the origin of several autoimmune events.
The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders
TLDR
The recent data on the roles of IL- 17A and IL-17F in inflammatory disorders and host defense are described and the potential of these molecules as therapeutic targets are discussed.
Interleukin 17‐Producing T Lymphocytes
TLDR
It is possible IL-17 production may serve as a biomarker for T lymphocytes possessing varied autoimmune disease-promoting effector functions and Regulation of T lymphocyte stability may have efficacy in the prevention of autoimmune disease.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 149 REFERENCES
Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses1
TLDR
It is demonstrated that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity.
Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
TLDR
It appears that splenic LTi-like cells are a rapid source of IL-17 and IL-22, which might contribute to dynamic organization of secondary lymphoid organ structure or host defense.
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
TLDR
In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
TLDR
Using passive transfer studies, it is confirmed that these IL-23–dependent CD4+ T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity.
IL-17 family cytokines and the expanding diversity of effector T cell lineages.
TLDR
The factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.
IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1
TLDR
It is demonstrated that, in naive mice, as well as during Mycobacterium tuberculosis infection, IL-17 production is primarily from γδ T cells and other non-CD4+CD8+ cells, rather than CD4 T cells.
Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17*
TLDR
Evidence is presented that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion, which suggests that during a secondary immune response, IL- 23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.
Th17 cells and mucosal host defense.
IL-17 and Th17 Cells.
TLDR
The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
IL-6 Promotes NK Cell Production of IL-17 during Toxoplasmosis
TLDR
Data indicate that many of the same cytokines that regulate Th17 cells are part of a conserved pathway that also control innate production of IL-17 and identify a major role for IL-6 in the regulation of NK cell responses.
...
1
2
3
4
5
...