Innate IL-17 and IL-22 responses to enteric bacterial pathogens.

  title={Innate IL-17 and IL-22 responses to enteric bacterial pathogens.},
  author={Stephen J. Rubino and Kaoru Geddes and Stephen E. Girardin},
  journal={Trends in immunology},
  volume={33 3},
With the identification of T helper (Th)17 cells, a specific subset of CD4 T cells expressing interleukin (IL)-17 and IL-22, research on the function of these cytokines initially largely focused on traditional adaptive immune responses. However, IL-17 and IL-22 enhance basic innate barrier defenses at mucosal surfaces, such as antimicrobial peptide production and neutrophil recruitment; both events that occur rapidly and precede adaptive phase immunity. At the intestinal mucosal surface, it is… CONTINUE READING
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